20.500.12556/RUL-136046 Matrix metalloproteinases as biomarkers and treatment targets in mesothelioma a systematic review Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with asbestos exposure. We have performed a systematic search of PubMed.gov and ClinicalTrials.gov databases to retrieve and review three groups of studies: studies of MMPs expression in tumor tissue or body fluids in patients with mesothelioma, studies of MMPs genetic variability, and studies of MMPs as potential novel drug targets in mesothelioma. Several studies of MMPs in mesothelioma tissues reported a link between higher expression levels of commonly studied MMPs and clinical parameters, such as overall survival. Fewer studies have investigated genetic variability of MMP genes. Nevertheless, these studies suggested that certain genetic variants in MMP genes can have either protective or tumor-promoting effects on mesothelioma patients. MMPs have been also reported as novel drug targets, but so far no clinical trials of MMP inhibitors are registered in mesothelioma. In conclusion, MMPs play an important role in mesothelioma, but further studies are needed to elucidate the potentials of MMPs as biomarkers and drug targets in mesothelioma. mesothelioma metalloproteinases genetic variability biomarker drug target mezoteliom metaloproteinaza genetska variabilnost true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-08 12:32:56 2022-04-08 12:32:59 2022-09-15 04:13:18 0000-00-00 00:00:00 2021 0 0 10 str. iss. 9, art. 1272 Vol. 11 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2218-273X 10.3390/biom11091272 74658819 RAZ_Strbac_Danijela_2021.pdf RAZ_Strbac_Danijela_2021.pdf 1 1CFB9E494B42D5760F81FD2169CCF7A0 b4ec37176b4000639fefda9e40256dc985d0ab9c2efafb89bbe967167d6923e9 6e545851-b727-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155486 https://www.mdpi.com/2218-273X/11/9/1272 1 37de89d0-b727-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155485 Medicinska fakulteta 0 0 0