20.500.12556/RUL-136042 Risk assessment of oxidative stress induced by metal ions released from fixed orthodontic appliances during treatment and indications for supportive antioxidant therapy a narrative review The treatment with fixed orthodontic appliances could have an important role in the induction of oxidative stress and associated negative consequences. Because of the simultaneous effects of corrosion, deformation, friction, and mechanical stress on fixed orthodontic appliances during treatment, degradation of orthodontic brackets and archwires occurs, causing higher concentrations of metal ions in the oral cavity. Corroded appliances cause the release of metal ions, which may lead to the increased values of reactive oxygen species (ROS) due to metal-catalyzed free radical reactions. Chromium, iron, nickel, cobalt, titanium, and molybdenum all belong to the group of transition metals that can be subjected to redox reactions to form ROS. The estimation of health risk due to the amount of heavy metals released and the level of selected parameters of oxidative stress generated for the time of treatment with fixed orthodontic appliances is presented. Approaches to avoid oxidative stress and recommendations for the preventive use of topical or systemic antioxidants during orthodontic treatment are discussed. fixed orthodontic appliances oxidative stress metal ions risk assessment antioxidant therapy ortodontski pripomočki oksidativni stres kovinski ioni vpliv na zdravje antioksidanti true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-08 11:22:56 2022-04-08 11:22:57 2022-09-15 04:13:18 0000-00-00 00:00:00 2021 0 0 17 str. iss. 9, art. 1359 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.314-089.23:546.7:66.094.3.097.8 2076-3921 10.3390/antiox10091359 74268163 RAZ_Primozic_Jasmina_2021.pdf RAZ_Primozic_Jasmina_2021.pdf 1 22AEE99C456F8A62682C03F0FC4A742B 4d296a79f8ddb9ccf7be47e9128ae63d0c91a52805f51e0415f0739edf3906d4 b02981a5-b71d-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155476 https://www.mdpi.com/2076-3921/10/9/1359 1 6f3d760a-b71d-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155474 Medicinska fakulteta Zdravstvena fakulteta Biotehniška fakulteta 0 0 0