20.500.12556/RUL-135958 A systematic review of therapeutic approaches used in experimental models of interstitial cystitis/bladder pain syndrome Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in vitro, ex vivo, and in vivo experimental models of IC/BPS. Publications were identified by electronic search of three online databases. Data were extracted for study design, type of treatment, main findings, and outcome, as well as for methodological quality and the reporting of measures to avoid bias. A total of 100 full-text articles were included. The majority of identified articles evaluated therapeutic agents currently recommended to treat IC/BPS by the American Urological Association guidelines (21%) and therapeutic agents currently approved to treat other diseases (11%). More recently published articles assessed therapeutic approaches using stem cells (11%) and plant-derived agents (10%), while novel potential drug targets identified were proteinase-activated (6%) and purinergic (4%) receptors, transient receptor potential channels (3%), microRNAs (2%), and activation of the cannabinoid system (7%). Our results show that the reported methodological quality of animal studies could be substantially improved, and measures to avoid bias should be more consistently reported in order to increase the value of preclinical research in IC/BPS for potential translation to a clinical setting. interstitial cystitis bladder pain syndrome therapeutic approaches experimental models in vitro ex vivo in vivo intersticijski cistitis bolečine v mehurju terapevtski pristopi true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-05 08:36:18 2022-04-05 08:36:27 2022-09-15 04:12:57 0000-00-00 00:00:00 2021 0 0 23 str. iss. 8, art. 865 Vol. 9 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 2227-9059 10.3390/biomedicines9080865 71570179 RAZ_Kuret_Tadeja_2021.pdf RAZ_Kuret_Tadeja_2021.pdf 1 5DA06F30EA276976A9A627E79C10E9A7 a05b522af485cb07ce3718c2a1b77879969f647a6a4be10dec18b34d03c10a7d e90d20cf-b4aa-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155295 https://www.mdpi.com/2227-9059/9/8/865 1 b15e6ee6-b4aa-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155294 Medicinska fakulteta 0 0 0