20.500.12556/RUL-135951 The potential of macroporous silica—nanocrystalline cellulose combination for formulating dry emulsion systems with improved flow properties a DoE study The objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil—drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated. simvastatin dry emulsion lipid-based drug delivery systems nanocrystalline cellulose macroporous silica spray drying flowability DoE suhe emulzije nanokristalinska celuloza sušenje z razprševanjem makroporozni kremen pretočnost dostavni sistem emulzije true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-04 14:48:37 2022-04-04 14:48:46 2023-03-15 09:22:50 0000-00-00 00:00:00 2021 0 0 24 str. iss. 8, art. 1177 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.14 1999-4923 10.3390/pharmaceutics13081177 72824835 RAZ_Pohlen_Mitja_2021.pdf RAZ_Pohlen_Mitja_2021.pdf 1 030D3CBA31C5D38AD9B0FC1C9F5AD1B8 7565ac8978ad37ce60c223f976dbc45cb795698e55b5ebe7e9d60e0a7ee40fdb c38dd534-b416-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155282 https://www.mdpi.com/1999-4923/13/8/1177 1 8abeda3d-b415-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155281 Fakulteta za farmacijo 0 0 0