20.500.12556/RUL-135884 The onset of depression in middle-aged presumed healthy Slovenian family practice attendees and its associations with genetic risk assessment, quality of life and health status a contribution for family medicine practitioners' early detection Despite depression being a major driver of morbidity and mortality, the majority of primary care patients remain undiagnosed, so this study aimed to assess the prevalence of depression and the association with demographic and clinical variables, genetic risk, and quality of life. The participants were presumably healthy model family medicine practice (MFMP) attendees between 30 and 65 years of age and recruited during a preventive check-up in 2019. Each of the 40 pre-selected MFMP pragmatically invited 30 attendees to voluntarily participate. They completed a questionnaire of demographic, clinical, and social determinants, as well as a three-generational family history. The results were analyzed using multivariable modelling to calculate the associations with signs of depression. A modified Scheuner method was used to calculate the level genetic risk level using family history. Of 968 participants, aged 42.8 ± 8.6 years, 627 (64.8%) were women. The prevalence of depression was 4.1%. Signs of depression were negatively associated with health-related quality of life score, in particular in the domains of self-care (p = 0.001) and anxiety/depression (p < 0.001). Depression was also associated with predicted high risk for comorbidities given the family history (p = 0.030). Primary care directed at improving patients’ quality of life should implement more widespread screening for mental health disorders. Family history for disease even beyond depression can be used by physicians as an important primary prevention tool. depression mental health quality of life health-related quality of life family practice middle-age comorbidities genetic risk primary prevention depresija duševno zdravje kakovost življenja true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-31 08:15:12 2022-03-31 08:15:16 2022-09-15 04:12:38 0000-00-00 00:00:00 2021 0 0 13 str. iss. 15, art. 8197 Vol. 18 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 1660-4601 10.3390/ijerph18158197 72124931 RAZ_Jerala_Nina_2021.pdf RAZ_Jerala_Nina_2021.pdf 1 604A32EBBCA7DAE67EA579757AAD962D 5c5befcd2798b803c31f1b6f8ae08a5ba061dae0a3b86556f5b0c4597c2c21b2 33cca72a-b0ba-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155120 https://www.mdpi.com/1660-4601/18/15/8197 1 e9f9b669-b0b9-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155118 Medicinska fakulteta 0 0 0