20.500.12556/RUL-135709 The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on varioustypes of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5,MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, wedescribe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formationas well as in non-hematopoietic tissues and tumor cells. Although the central framework of thesepathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineagedifferences. We summarize the current state of research in this field, highlight the novel members ofEPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroidand non-erythroid cells. erythropoietin PI3K MAPK eritropoetin PI3K MAPK true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-29 11:49:51 2022-03-29 11:49:54 2022-09-14 04:14:46 0000-00-00 00:00:00 2021 0 0 14 str. iss. 14, art. 7682 Vol. 22 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1422-0067 10.3390/ijms22147682 71385603 RAZ_Tothova_Zuzana_2021.pdf RAZ_Tothova_Zuzana_2021.pdf 1 C3B5D3B7854AF23C3622F8FF547B7850 fd6c6a5ea3689d8c9f1ae39958e411cda96bd8b0caf42042f16c64e1cc4fc2eb c7ee5fd5-af45-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154960 https://www.mdpi.com/1422-0067/22/14/7682 1 9190ea31-af45-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154959 Medicinska fakulteta 0 0 0