20.500.12556/RUL-135617 Quality control of vitamins A and E and coenzyme Q10 in commercial anti-ageing cosmetic products Vitamins A and E and coenzyme Q10 are common ingredients in anti-ageing cosmetic products. Within this study, we evaluated the quality of commercial cosmetics with vitamin A (35 products), vitamin E (49 products), and coenzyme Q10 (27 products) by using validated HPLC– UV methods. Vitamin A was determined as retinol, retinyl palmitate, retinyl propionate, β carotene, and hydroxypinacolone retinoate in concentrations ranging from 950 ng/g to 19 mg/g. Total vitamin A contents, expressed with retinol equivalents, ranged from 160 ng/g to 19 mg/g, and were above the maximum concentration recommended by the SCCS in six of the 35 tested cosmetics. The content-related quality control of 10 cosmetics with specified vitamin A content revealed significant deviations (between 0% and 400%) of the label claim. Vitamin E was determined as both tocopherol and tocopheryl acetate in concentrations between 8.5 µg/g and 16 mg/g. Coenzyme Q10 was determined as ubiquinone in 24 tested cosmetics, which labelled it, in concentrations between 4.2 µg/g and 100 µg/g. Labelling irregularities were observed in all three active compound groups, resulting in a significant share (42%) of improperly labelled cosmetic products. The results of this study reveal the need for stricter cosmetics regulation and highlight the importance of their quality control, especially by evaluating the contents of the active compounds, in their efficacy and safety assurance. active compounds assay cosmeceutics functional cosmetics HPLC-UV labelling retinoids tocopherol ubiquinone β carotene aktivne spojine testi funkcionalna kozmetika označevanje tokoferol retinoidi vitamin A vitamin E beta karoten kozmetični izdelki ubikinon true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-22 11:33:47 2022-03-22 11:33:50 2022-09-14 04:14:17 0000-00-00 00:00:00 2021 0 0 17 str. iss. 3, art. 61 Vol. 8 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.161.6:665.58 2079-9284 10.3390/cosmetics8030061 83392003 RAZ_Temova_Rakusa_Zane_2021.pdf RAZ_Temova_Rakusa_Zane_2021.pdf 1 3080540F7BA1ECB2A4F97E32BBA1F704 c310ab8b70f7eaa1f62cafcf22567c6121a8c693bb9118e320971cb05e083b2d d2850b4b-a9cb-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154806 https://www.mdpi.com/2079-9284/8/3/61 1 8fc8742b-a9cb-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154805 Fakulteta za farmacijo 0 0 0