20.500.12556/RUL-135586 Regulation of oxygen homeostasis at the intestinal epithelial barrier site The unique biology of the intestinal epithelial barrier is linked to a low baseline oxygen pressure (pO$_2$), characterised by a high rate of metabolites circulating through the intestinal blood and the presence of a steep oxygen gradient across the epithelial surface. These characteristics require tight regulation of oxygen homeostasis, achieved in part by hypoxia-inducible factor (HIF)-dependent signalling. Furthermore, intestinal epithelial cells (IEC) possess metabolic identities that are reflected in changes in mitochondrial function. In recent years, it has become widely accepted that oxygen metabolism is key to homeostasis at the mucosae. In addition, the gut has a vast and diverse microbial population, the microbiota. Microbiome–gut communication represents a dynamic exchange of mediators produced by bacterial and intestinal metabolism. The microbiome contributes to the maintenance of the hypoxic environment, which is critical for nutrient absorption, intestinal barrier function, and innate and/or adaptive immune responses in the gastrointestinal tract. In this review, we focus on oxygen homeostasis at the epithelial barrier site, how it is regulated by hypoxia and the microbiome, and how oxygen homeostasis at the epithelium is regulated in health and disease. oxygen mitochondria hypoxia microbiota IBD kisik mitohondriji hipoksija mikrobiota bolezni črevesja true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-21 13:41:02 2022-03-21 13:41:03 2022-09-14 04:14:07 0000-00-00 00:00:00 2021 0 0 15 str. iss. 17, art. 9170 Vol. 22 Sep. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.2:616.34 1422-0067 10.3390/ijms22179170 74311427 RAZ_Konjar_Spela_2021.pdf RAZ_Konjar_Spela_2021.pdf 1 AB787802E4FCE02E03ED6E947BC8FC4F a9f46c6d301ee1d13af7b1ac6725b314890748f112c5cae0405986326a4f4a45 6d7c33fc-a914-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154743 https://www.mdpi.com/1422-0067/22/17/9170 0 2c0404d4-a914-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154742 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0