20.500.12556/RUL-135544 Comparison of clinical, laboratory and immune characteristics of the monophasic and biphasic course of tick-borne encephalitis The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Patients with the monophasic course were significantly (p ≤ 0.002) older (57 vs. 50 years), more often vaccinated against TBE (7.4% vs. 0.9%), more often had comorbidities (52% vs. 37%), and were more often treated in the intensive care unit (12.4% vs. 5.2%). Multivariate logistic regression found strong association between the monophasic TBE course and previous TBE vaccination (OR = 18.45), presence of underlying illness (OR = 1.85), duration of neurologic involvement before cerebrospinal fluid (CSF) examination (OR = 1.39), and patients’ age (OR = 1.02). Furthermore, patients with monophasic TBE had higher CSF levels of immune mediators associated with innate and adaptive (Th1 and B-cell) immune responses, and they had more pronounced disruption of the blood–brain barrier. However, the long-term outcome 2–7 years after TBE was comparable. In summary, the monophasic course is a frequent and distinct presentation of TBE that is associated with more difficult disease course and higher levels of inflammatory mediators in CSF than the biphasic course; however, the long-term outcome is similar. tick-borne encephalitis monophasic course biphasic course long-term outcome cerebrospinal fluid cytokines chemokines innate immune responses adaptive immune responses klopni encefalitis cerebralna tekočina citokini imunski odziv true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-18 08:46:37 2022-03-18 08:46:39 2022-09-14 04:13:55 0000-00-00 00:00:00 2021 0 0 12 str. iss. 4, art. 796 Vol. 9 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 606.9 2076-2607 10.3390/microorganisms9040796 59073539 RAZ_Bogovic_Petra_2021.pdf RAZ_Bogovic_Petra_2021.pdf 1 1089A951694C78DBC6B2C4D021AF0499 1cb2aa8fc342dea059883ffa7e8976ebc11541216b23db88e94bb0cf2c511b7f 94663cf8-a690-11ec-960c-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154672 https://www.mdpi.com/2076-2607/9/4/796 1 8c133dd4-a68f-11ec-960c-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154671 Medicinska fakulteta 0 0 0