20.500.12556/RUL-135364 Microwave-assisted regioselective Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids Suzuki coupling reaction has been often used for the preparation of a diverse set of substituted pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation led to a very efficient and straightforward synthetic procedure providing C4-substituted pyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings. cross-coupling Suzuki palladium pyrimidines synthesis microwave-assisted pirimidin boronska kislina sinteza spojin farmacevtska kemija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-09 09:28:01 2022-03-09 09:28:03 2022-09-14 04:13:01 0000-00-00 00:00:00 2021 0 0 16 str. iss. 4, art. 439 Vol. 11 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.4:54:547 2073-4344 10.3390/catal11040439 59092995 RAZ_Dolsak_Ana_2021.pdf RAZ_Dolsak_Ana_2021.pdf 1 A6F17C576B53AC0616D82887092108CF 6e2ddd7b1f2f6ec72cef38d106fc7571499cb0fb20285590a7dd515cf3c21a71 d0a0cc92-9f82-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154401 https://www.mdpi.com/2073-4344/11/4/439 1 8f0ae9d2-9f82-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154400 Fakulteta za farmacijo 0 0 0