20.500.12556/RUL-135362 Are differences in presentation of early Lyme borreliosis in Europe and North America a consequence of a more frequent spirochetemia in American patients? To assess whether differences in presentation between US and European patients with early Lyme borreliosis are due to the lower rate of spirochetemia in Europe, we compared multiple variables for patients with erythema migrans (EM), restricting the analysis to subjects with a positive blood culture at the time of presentation: 93 US patients infected with Borrelia burgdorferi versus 183 European patients infected with Borrelia afzelii (No = 144) or Borrelia garinii (No = 39). Compared to spirochetemic Slovenian EM patients infected with B. afzelii, US patients with a positive blood culture significantly less often recalled a preceding tick bite at the site of the EM skin lesion, had a shorter duration of EM prior to diagnosis and more often had multiple EM lesions, regional lymphadenopathy, constitutional symptoms, an increased ESR value, a low blood lymphocyte count and detectable borrelia antibodies in acute and convalescent phase blood samples. Similar differences were observed when US patients were compared to Slovenian patients with B. garinii infection, but not all reached statistical significance. The findings are comparable to those previously reported for the corresponding skin culture positive patients and do not support the hypothesis that a higher frequency of spirochetemia at the time of presentation in US patients with EM, compared with European EM patients, is the reason for the observed differences. Borrelia burgdorferi Borrelia afzelii Borrelia garinii Lyme borreliosis isolation blood USA Europe Borrelia burgdorferi Borrelia afzelii Borrelia garinii lymska borelioza izolacija kri ZDA Evropa true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-09 08:35:09 2022-03-09 08:35:11 2022-09-14 04:12:59 0000-00-00 00:00:00 2021 0 0 8 str. iss. 7, art. 1448 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2077-0383 10.3390/jcm10071448 59069699 RAZ_Maraspin-Carman_Vera_2021.pdf RAZ_Maraspin-Carman_Vera_2021.pdf 1 33C48560C53705EF08AAB76F6BCFBA47 6ffaa0f58c9abaae08c955aa47fed6f3fb683b460637ee42ed2d7ae4ff935234 99508c93-9f7b-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154397 https://www.mdpi.com/2077-0383/10/7/1448 0 2bda923c-9f7b-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154396 Medicinska fakulteta 0 0 0