20.500.12556/RUL-135345 Structural characterization, antimicrobial activity and BSA/DNA binding affinity of new silver(I) complexes with thianthrene and 1,8-naphthyridine Three new silver(I) complexes [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ (Ag1), [Ag(CF$_3$SO$_3$)(1,8-naph)]$_n$ (Ag2) and [Ag$_2$(1,8-naph)$_2$(H$_2$O)$_{1.2}$](PF$_6$)$_2$ (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56–7.81 µg/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1–3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids. silver(I) complexes thianthrene 1 8-naphthyridine antimicrobial activity Caenorhabditis elegans DNA/BSA interaction srebro(I) srebrovi kompleksi true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-08 13:54:23 2022-03-08 13:54:24 2022-09-14 04:12:54 0000-00-00 00:00:00 2021 0 0 20 str. iss. 7, art. 1871 Vol. 26 Apr. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.571 1420-3049 10.3390/molecules26071871 57510915 RAZ_Asanin_Darko_P._2021.pdf RAZ_Asanin_Darko_P._2021.pdf 1 5C62AD59DD25D617047319269A69CAA4 b7d5eca308a825447089156ce1f14f0e4ba8bdbb76b97e1bb4f7756dadf1fee5 2bf29da4-9edf-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154371 https://www.mdpi.com/1420-3049/26/7/1871 0 99ef629a-9ede-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154370 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0