20.500.12556/RUL-135237 New cross-talks between pathways involved in grapevine infection with ʼCandidatus Phytoplasma solaniʼ revealed by temporal network modelling Understanding temporal biological phenomena is a challenging task that can be approached using network analysis. Here, we explored whether network reconstruction can be used to better understand the temporal dynamics of bois noir, which is associated with ‘Candidatus Phytoplasma solani’, and is one of the most widespread phytoplasma diseases of grapevine in Europe. We proposed a methodology that explores the temporal network dynamics at the community level, i.e., densely connected subnetworks. The methodology offers both insights into the functional dynamics via enrichment analysis at the community level, and analyses of the community dissipation, as a measure that accounts for community degradation. We validated this methodology with cases on experimental temporal expression data of uninfected grapevines and grapevines infected with ‘Ca. P. solani’. These data confirm some known gene communities involved in this infection. They also reveal several new gene communities and their potential regulatory networks that have not been linked to ‘Ca. P. solani’ to date. To confirm the capabilities of the proposed method, selected predictions were empirically evaluated. community detection enrichment analysis network analysis phytoplasma bois noir analiza omrežij fitoplazme počrnelost lesa true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-02 10:18:21 2022-03-02 10:18:24 2022-09-14 04:12:21 0000-00-00 00:00:00 2021 0 0 18 str. iss. 4, art. 646 Vol. 10 Apr. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 2223-7747 10.3390/plants10040646 58899971 RAZ_Skrlj_Blaz_2021.pdf RAZ_Skrlj_Blaz_2021.pdf 1 8E524196E08CE4930624916719FF4649 fe5cda1a9fee27e5dfc2e4d514e5c412d29bc3b55ac5a220c38061ea5ae97f10 a6056ad1-9a09-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154179 https://www.mdpi.com/2223-7747/10/4/646 1 71d17021-9a09-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154178 Biotehniška fakulteta 0 0 0