20.500.12556/RUL-135199 New insights into antibacterial and antifungal properties, cytotoxicity and aquatic ecotoxicity of flame retardant PA6/DOPO-derivative nanocomposite textile fibers The aim of this study was to evaluate the antibacterial and antifungal activity, cytotoxicity, leaching, and ecotoxicity of novel flame retardant polyamide 6 (PA6) textile fibers developed by our research group. The textile fibers were produced by the incorporation of flame-retardant bridged 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative (PHED) in the PA6 matrix during the in situ polymerization process at concentrations equal to 10 and 15 wt% (PA6/10PHED and PA6/15PHED, respectively). Whilst the nanodispersed PHED provided highly efficient flame retardancy, its biological activity led to excellent antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as excellent antifungal activity against Aspergillus niger and Candida albicans. The results confirmed leaching of the PHED, but the tested leachates did not cause any measurable toxic effect to the duckweed Lemna minor. The in vitro cytotoxicity of the leached PHED from the PA6/15PHED sample was confirmed for human cells from adipose tissue in direct and prolonged contact. The targeted biological activity of the organophosphinate flame retardant could be beneficial for the development of PA6 textile materials with multifunctional properties and the low ecotoxicity profile, while the PHED’s leaching and cytotoxicity limit their application involving the washing processes and direct contact with the skin. polyamide 6 textile filament DOPO derivative antibacterial activity antifungal activity ecotoxicity cytotoxicity poliamid 6 tekstilni filament DOPO derivat antibakterijsko delovanje protiglivično delovanje ekotoksičnost citotoksičnost true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-28 13:50:55 2022-02-28 13:50:56 2022-09-14 04:12:07 0000-00-00 00:00:00 2021 0 0 17 str. iss. 6, art. 905 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677 2073-4360 10.3390/polym13060905 55570947 RAZ_Vasiljevic_Jelena_2021.pdf RAZ_Vasiljevic_Jelena_2021.pdf 1 D81CCC6C726FCE0FE26D78DAB969F014 27f18cbfc93044b88e5fb930c4d78491338f04ba7a9be81bcc812462d728cc7f 3f4cb422-9895-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154106 https://www.mdpi.com/2073-4360/13/6/905 1 cf02094a-9894-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154105 Naravoslovnotehniška fakulteta Fakulteta za kemijo in kemijsko tehnologijo 0 0 0