20.500.12556/RUL-135197 Vitamin A and retinoids in bladder cancer chemoprevention and treatment a narrative review of current evidence, challenges and future prospects Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets. bladder cancer vitamin A retinoic acid signalling retinoids chemoprevention treatment experimental bladder cancer models clinical trials delivery systems novel targets rak mehurja vitamin A signalizacija retinojske kisline true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-28 13:35:28 2022-02-28 13:35:34 2022-09-14 04:12:06 0000-00-00 00:00:00 2021 0 0 19 str. iss. 7, art. 3510 Vol. 22 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.7 1422-0067 10.3390/ijms22073510 57932035 RAZ_Tratnjek_Larisa_2021.pdf RAZ_Tratnjek_Larisa_2021.pdf 1 FDD89206247753030C0CE87DFF123FF7 d5984874833711f8d11558390f1e5efc47309f3233c856a99c6ec8d578600268 e5e51a98-9892-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154103 https://www.mdpi.com/1422-0067/22/7/3510 0 a8ee6e8f-9892-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154102 Medicinska fakulteta 0 0 0