20.500.12556/RUL-135060 Stability of reduced and oxidized coenzyme Q10 in finished products The efficiency of coenzyme Q10 (CoQ10) supplements is closely associated with its content and stability in finished products. This study aimed to provide evidence-based information on the quality and stability of CoQ10 in dietary supplements and medicines. Therefore, ubiquinol, ubiquinone, and total CoQ10 contents were determined by a validated HPLC-UV method in 11 commercial products with defined or undefined CoQ10 form. Both forms were detected in almost all tested products, resulting in a total of CoQ10 content between 82% and 166% of the declared. Ubiquinol, ubiquinone, and total CoQ10 stability in these products were evaluated within three months of accelerated stability testing. Ubiquinol, which is recognized as the less stable form, was properly stabilized. Contrarily, ubiquinone degradation and/or reduction were observed during storage in almost all tested products. These reactions were also detected at ambient temperature within the products shelf-lives and confirmed in ubiquinone standard solutions. Ubiquinol, generated by ubiquinone reduction with vitamin C during soft-shell capsules storage, may lead to higher bioavailability and health outcomes. However, such conversion and inappropriate content in products, which specify ubiquinone, are unacceptable in terms of regulation. Therefore, proper CoQ10 stabilization through final formulations regardless of the used CoQ10 form is needed. assay coenzyme Q10 content commercial products dietary supplements HPLC-UV medicines reducing agent stability ubiquinol ubiquinone koencim 10 stabilnost učinkovin ubikinon prehranska dopolnila true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-18 16:03:38 2022-02-18 16:03:41 2023-03-15 09:47:36 0000-00-00 00:00:00 2021 0 0 17 str. iss. 3, art. 360 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.161.6:613.292 2076-3921 10.3390/antiox10030360 53472259 RAZ_Temova_Rakusa_Zane_2021.pdf RAZ_Temova_Rakusa_Zane_2021.pdf 1 79DB476869FB226BC0470D51868EF7BD f335c7225c8fb3ad0946f6830c8fb8c8307750d490bab8214618620889892a13 3f6a6531-90cc-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153910 https://www.mdpi.com/2076-3921/10/3/360 1 b6c94f14-90cb-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153909 Fakulteta za farmacijo 0 0 0