20.500.12556/RUL-135014 Low virus-specific IgG antibodies in adverse clinical course and outcome of tick-borne encephalitis Tick-borne encephalitis (TBE) is associated with a range of disease severity. The reasons for this heterogeneity are not clear. Levels of serum IgG antibodies to TBE virus (TBEV) were determined in 691 adult patients during the meningoencephalitic phase of TBE and correlated with detailed clinical and laboratory parameters during acute illness and with the presence of post-encephalitic syndrome (PES) 2–7 years after TBE. Specific IgG antibody levels ranged from below cut-off value (in 32/691 patients, 4.6%), to 896 U/mL (median = 37.3 U/mL). Patients with meningoencephalomyelitis were more often seronegative (24.3%; 9/37) than those with meningoencephalitis (4.7%; 20/428) or meningitis (1.3%; 3/226). Moreover, patients with antibody levels below cut-off had longer hospitalization (13 versus 8 days); more often required intensive care unit treatment (22% versus 8%) and artificial ventilation (71% versus 21%); and had a higher fatality rate (3/32; 9.4% versus 1/659; 0.2%) than seropositive patients. These results were confirmed when antibody levels, rather than cut-off values, were correlated with clinical parameters including the likelihood to develop PES. Low serum IgG antibody responses against TBEV at the onset of neurologic involvement are associated with a more difficult clinical course and unfavorable long-term outcome of TBE, providing a diagnostic and clinical challenge for physicians. tick-borne encephalitis humoral immune response serum IgG antibodies course outcome true false true Angleški jezik Ni določen Članek v reviji 2022-02-17 11:03:46 2022-02-17 11:03:47 2022-09-14 04:11:11 0000-00-00 00:00:00 2021 0 0 12 str. iss. 2, art. 332 Vol. 9 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2076-2607 10.3390/microorganisms9020332 51124995 RAZ_Bogovic_Petra_2021.pdf RAZ_Bogovic_Petra_2021.pdf 1 AE14D21037EFA54A283A3AB663E45037 a22df857249a7631e42a10b83ff809f62a8599c4f1991f55d93aa9c90334bee5 ed4db0de-8fd8-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153831 https://www.mdpi.com/2076-2607/9/2/332 1 a7a75fdc-8fd8-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153829 Medicinska fakulteta 0 0 0