20.500.12556/RUL-134985 Activity flow underlying abnormalities in brain activations and cognition in schizophrenia Cognitive dysfunction is a core feature of many brain disorders such as schizophrenia (SZ), and has been linked to both aberrant brain functional connectivity (FC) and aberrant cognitive brain activations. We propose that aberrant network activity flow over FC pathways leads to altered cognitive activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping - an approach that models the movement of task-related activity between brain regions as a function of FC. Using fMRI data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in independent patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to the emergence of cognitive dysfunction in SZ. activity flow schizophrenia brain neurosciences cognitive impairment cognitive dysfunction functional connectivity neural networks brain networks functional magnetic resonance imaging fMRI working memory tok aktivnosti shizofrenija možgani nevroznanost kognitivni upad kognitivna motnja funkcijska konektivnost nevronske mreže možganska omrežja funkcijsko magnetnoresonančno slikanje fMRI delovni spomin true false false Angleški jezik Slovenski jezik Neznano 2022-02-16 09:51:18 2022-02-16 09:51:22 2022-09-14 04:11:01 0000-00-00 00:00:00 2021 0 0 Str. 1-13 iss. 29 Vol. 7 2021 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 159.91:616.895.8 2375-2548 10.1126/sciadv.abf2513 48459779 RAZ_Hearne_Luke_J._2021.pdf RAZ_Hearne_Luke_J._2021.pdf 1 82EB1CAB6C2F9E7E0662A923F3767C30 deebef0fa48541bb4ebbb6e8bb9bcd0ec015e3663b2e9188a79c3a3510f7acfc 378aaf14-8f23-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153789 https://www.science.org/doi/10.1126/sciadv.abf2513# 0 49b88443-8f23-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153790 Filozofska fakulteta 0 0 0