20.500.12556/RUL-134898 Epigenetics of Alzheimer's disease There are currently no validated biomarkers which can be used to accurately diagnose Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies. Moreover, to date, only symptomatic treatments exist for this progressive neurodegenerative disorder. In the search for new, more reliable biomarkers and potential therapeutic options, epigenetic modifications have emerged as important players in the pathogenesis of AD. The aim of the article was to provide a brief overview of the current knowledge regarding the role of epigenetics (including mitoepigenetics) in AD, and the possibility of applying these advances for future AD therapy. Extensive research has suggested an important role of DNA methylation and hydroxymethylation, histone posttranslational modifications, and non-coding RNA regulation (with the emphasis on microRNAs) in the course and development of AD. Recent studies also indicated mitochondrial DNA (mtDNA) as an interesting biomarker of AD, since dysfunctions in the mitochondria and lower mtDNA copy number have been associated with AD pathophysiology. The current evidence suggests that epigenetic changes can be successfully detected, not only in the central nervous system, but also in the cerebrospinal fluid and on the periphery, contributing further to their potential as both biomarkers and therapeutic targets in AD. Alzheimer's disease epigenetics DNA methylation mitoepigenetics DNA hydroxymethylation miRNA histone modifications Alzheimerjeva bolezen epigenetika metilacija DNA true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-10 14:00:41 2022-02-10 14:00:42 2022-09-14 04:10:34 0000-00-00 00:00:00 2021 0 0 38 str. iss. 2, art. 195 Vol. 11 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2218-273X 10.3390/biom11020195 49661699 RAZ_Nikolac_Perkovic_Matea_2021.pdf RAZ_Nikolac_Perkovic_Matea_2021.pdf 1 D20FB3EE61562FE558B7D78E3675ADDB ef7c01fd0e052283fc7719dc85a22d44d1a8adb0a90845e79713036c2e62eef2 9f77532d-8a71-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153635 https://www.mdpi.com/2218-273X/11/2/195 1 393b8e6e-8a71-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153634 Medicinska fakulteta 0 0 0