20.500.12556/RUL-134844 Tie-2, G-CSF, and leptin as promising diagnostic biomarkers for endometrial cancer a pilot study Preoperative determination of the extent of endometrial cancer (EC) would avoid the complications associated with radical surgery. Screening of patients' plasma biomarkers might enable a more precise diagnosis of EC and a tailored treatment approach. This prospective case-control monocentric pilot study included 76 postmenopausal women (38 endometrioid EC patients and 38 control patients with benign gynecological conditions), and 37 angiogenic factors (AFs) were investigated as potential biomarkers for EC. AF concentrations in preoperative plasma samples were measured using Luminex xMAP$^{TM}$ multiplexing technology. The plasma levels of sTie-2 and G-CSF were significantly lower in EC compared to control patients, whereas the plasma levels of leptin were significantly higher in EC patients. Neuropilin-1 plasma levels were significantly higher in patients with type 2 EC (grade 3) compared to patients with lower grade cancer or controls. Follistatin levels were significantly higher in patients with lymphovascular invasion, and IL-8 plasma levels were significantly higher in patients with metastases. If validated, the plasma concentrations of the indicated AFs could represent an important additional diagnostic tool for the early detection and characterization of EC. This could guide the decision-making on the extent of surgery. Further studies with larger patient numbers are currently ongoing. endometrial cancer angiogenesis biomarkers angiogenic factors Tie-2 G-CSF leptin rak endometrija angiogeneza biomarkerji true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-04 10:12:20 2022-02-04 10:12:25 2022-09-14 04:10:17 0000-00-00 00:00:00 2021 0 0 11 str. iss. 4, art. 765 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2077-0383 10.3390/jcm10040765 51545347 RAZ_Roskar_Luka_2021.pdf RAZ_Roskar_Luka_2021.pdf 1 9E833F89723BE8B309944CC14BA1C113 9232e4cce5513943afbd2490d2a5c6b3909b465daac3b95c774299b362cbcbf4 c767754d-859a-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153537 https://www.mdpi.com/2077-0383/10/4/765 1 58c4bc89-859a-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153536 Medicinska fakulteta 0 0 0