20.500.12556/RUL-134836 A prospective phase II study evaluating intraoperative electrochemotherapy of hepatocellular carcinoma The aim of this clinical study was to investigate the effectiveness and long-term safety of electrochemotherapy as an emerging treatment for HCC in patients not suitable for other treatment options. A prospective phase II clinical study was conducted in patients with primary HCC who were not suitable for other treatment options according to the Barcelona Clinic Liver Cancer classification. A total of 24 patients with 32 tumors were treated by electrochemotherapy. The procedure was effective, feasible, and safe with some procedure-related side effects. The responses of the 32 treated nodules were: 84.4% complete response (CR), 12.5% partial response (PR), and 3.1% stable disease (SD). The treatment was equally effective for nodules located centrally and peripherally. Electrochemotherapy provided a durable response with local tumor control over 50 months of observation in 78.0% of nodules. The patient responses were: 79.2% CR and 16.6% PR. The median progression-free survival was 12 months (range 2.7–50), and the overall survival over 5 years of observation was 72.0%. This prospective phase II clinical study showed that electrochemotherapy was an effective, feasible, and safe option for treating HCC in patients not suitable for other treatment options. electrochemotherapy hepatocellular carcinoma open surgery liver cancer bleomycin elektrokemoterapija hepatocelularni rak kirurgija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-03 17:02:47 2022-02-03 17:02:50 2022-09-14 04:10:14 0000-00-00 00:00:00 2020 0 0 14 str. iss. 12, art. 3778 Vol. 12 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602 2072-6694 10.3390/cancers12123778 42834691 RAZ_Djokic_Mihajlo_2020.pdf RAZ_Djokic_Mihajlo_2020.pdf 1 2D64E62A853DA73CB9748CC10EE3A466 ffa64c9ad48b3174a5c2a98af5b59e44dc84919915def759a3300b89e64a018a bc1991d8-850b-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153520 https://www.mdpi.com/2072-6694/12/12/3778 0 9b73244b-850a-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153519 Medicinska fakulteta Fakulteta za elektrotehniko Zdravstvena fakulteta 0 0 0