20.500.12556/RUL-134781 CARD8 and IL1B polymorphisms influence MRI brain patterns in newborns with hypoxic-ischemic encephalopathy treated with hypothermia Inflammation and oxidative stress are recognized as important contributors of brain injury in newborns due to a perinatal hypoxic-ischemic (HI) insult. Genetic variability in these pathways could influence the response to HI and the outcome of brain injury. The aim of our study was to evaluate the impact of common single-nucleotide polymorphisms in the genes involved in inflammation and response to oxidative stress on brain injury in newborns after perinatal HI insult based on the severity and pattern of magnetic resonance imaging (MRI) findings. The DNA of 44 subjects was isolated from buccal swabs. Genotyping was performed for NLRP3 rs35829419, CARD8 rs2043211, IL1B rs16944, IL1B rs1143623, IL1B rs1071676, TNF rs1800629, CAT rs1001179, SOD2 rs4880, and GPX1 rs1050450. Polymorphism in CARD8 was found to be protective against HI brain injury detected by MRI overall findings. Polymorphisms in IL1B were associated with posterior limb of internal capsule, basal ganglia, and white matter brain patterns determined by MRI. Our results suggest a possible association between genetic variability in inflammation- and antioxidant-related pathways and the severity of brain injury after HI insult in newborns. hypoxic-ischemic encephalopathy inflammation newborn oxidative stress polymorphism MRI hipoksično-ishemična encefalopatija vnetje novorojenček true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-01 14:55:30 2022-02-01 14:55:35 2022-09-14 04:09:52 0000-00-00 00:00:00 2021 0 0 14 str. iss. 1, art. 96 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002 2076-3921 10.3390/antiox10010096 47469571 RAZ_Esih_Katarina_2021.pdf RAZ_Esih_Katarina_2021.pdf 1 BCA0D5873F9AC6E2AAD7E90568900184 2c51142779c22b267d6b6e028f2e559a73eb478c8bdeb8b9494a9eb5c045d35c 9f9e6ada-8366-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153421 https://www.mdpi.com/2076-3921/10/1/96 1 6a10b285-8366-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153420 Medicinska fakulteta 0 0 0