20.500.12556/RUL-134411 The influence of probiotics on the Firmicutes/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and Bacteroidetes, have gained much attention in recent years. The Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to have an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiosis, whereby the former is usually observed with obesity, and the latter with inflammatory bowel disease (IBD). Probiotics as live microorganisms can confer health benefits to the host when administered in adequate amounts. There is considerable evidence of their nutritional and immunosuppressive properties including reports that elucidate the association of probiotics with the F/B ratio, obesity, and IBD. Orally administered probiotics can contribute to the restoration of dysbiotic microbiota and to the prevention of obesity or IBD. However, as the effects of different probiotics on the F/B ratio differ, selecting the appropriate species or mixture is crucial. The most commonly tested probiotics for modifying the F/B ratio and treating obesity and IBD are from the genus Lactobacillus. In this paper, we review the effects of probiotics on the F/B ratio that lead to weight loss or immunosuppression. probiotics Firmicutes Bacteroidetes dysbiosis obesity inflammation true false true Angleški jezik Ni določen Članek v reviji 2022-01-13 16:00:28 2022-01-13 16:00:28 2022-09-13 03:54:59 0000-00-00 00:00:00 2020 0 0 16 str. iss. 11, art. 1715 Vol. 8 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 2076-2607 10.3390/microorganisms8111715 35189763 RAZ_Stojanov_Spase_2020.pdf RAZ_Stojanov_Spase_2020.pdf 1 006C2C302BADE23A2E8199690D2B7669 436cf697e19480a3964384a7855fae262cdd078373489e23c73159e6fbc4d57b b43cb291-7481-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152851 https://www.mdpi.com/2076-2607/8/11/1715 0 75b17d31-7481-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152850 Fakulteta za farmacijo 0 0 0