20.500.12556/RUL-134349 Noninvasive monitoring of dynamical processes in bruised human skin using diffuse reflectance spectroscopy and pulsed photothermal radiometry We have augmented a recently introduced method for noninvasive analysis of skin structure and composition and applied it to monitoring of dynamical processes in traumatic bruises. The approach combines diffuse reflectance spectroscopy in visible spectral range and pulsed photothermal radiometry. Data from both techniques are analyzed simultaneously using a numerical model of light and heat transport in a four-layer model of human skin. Compared to the earlier presented approach, the newly introduced elements include two additional chromophores (β-carotene and bilirubin), individually adjusted thickness of the papillary dermal layer, and analysis of the bruised site using baseline values assessed from intact skin in its vicinity. Analyses of traumatic bruises in three volunteers over a period of 16 days clearly indicate a gradual, yet substantial increase of the dermal blood content and reduction of its oxygenation level in the first days after injury. This is followed by the emergence of bilirubin and relaxation of all model parameters towards the values characteristic for healthy skin approximately two weeks after the injury. The assessed parameter values and time dependences are consistent with existing literature. Thus, the presented methodology offers a viable approach for objective characterization of the bruise healing process. traumatic bruise contusion bilirubin diffuse reflectance spectroscopy integrating sphere pulsed photothermal radiometry inverse Monte Carlo true false true Angleški jezik Ni določen Članek v reviji 2022-01-10 08:25:46 2022-01-10 08:25:48 2022-09-13 03:54:39 0000-00-00 00:00:00 2021 0 0 19 str. iss. 1, art. 302 Vol. 21 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 54 1424-8220 10.3390/s21010302 45594371 RAZ_Marin_Ana_2021.pdf RAZ_Marin_Ana_2021.pdf 1 F4AA6AF73CA30A44B5AA3015B0CF5622 7c852e40163bf7b1a5de3c02c416982c03db943e40aa725970ddd8c9c3a004cf a34cc265-8e5e-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153764 https://www.mdpi.com/1424-8220/21/1/302 0 915889cd-71e7-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152750 Fakulteta za matematiko in fiziko 0 0 0