20.500.12556/RUL-134269 A comprehensive study of cutaneous fibropapillomatosis in free-ranging roe deer (Capreolus capreolus) and red deer (Cervus elaphus) from clinical manifestations to whole-genome sequencing of papillomaviruses Papillomaviruses (PVs) are an extremely large group of viruses that cause skin and mucosa infections in humans and various animals. In roe deer and red deer, most PVs belong to the Deltapapillomavirus genus and cause neoplastic changes that are generally described as fibropapillomas. Despite the wide distribution of roe and red deer throughout Europe and beyond, the data in the scientific literature regarding the widespread distribution of PVs and the genetic variability of PV genomes in these species are rather scarce. This study describes cutaneous fibropapillomatosis cases in roe and red deer with clinical manifestations that are typical of infections with PVs. In all cases, the presence of PV DNA was confirmed using PCR, followed by Sanger sequencing of the partial L1 gene. The complete PV genomes were determined in all the investigated samples using next-generation sequencing technology, revealing infections of roe deer with the CcaPV1-type and red deer with the CePV1v-type variant. A comparison of the complete CcaPV1-type and CePV1v-type variant genome sequences reported here with already available complete genome sequences in GenBank revealed their great genetic stability across time and space. papillomavirus fibropapillomatosis red deer roe deer genome NGS Papillomaviridae deer true false true Angleški jezik Ni določen Članek v reviji 2022-01-04 10:44:10 2022-01-04 10:44:10 2022-09-13 03:54:18 0000-00-00 00:00:00 2020 0 0 14 str. iss. 9, art. 1001 Vol. 12 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 578 1999-4915 10.3390/v12091001 27616515 RAZ_Kmetec_Jernej_2020.pdf RAZ_Kmetec_Jernej_2020.pdf 1 74D4C3182C5E4A428B38870793529416 8918af6621a1e49475395e138e3504f1e0c1882c0c1c66bee4980774e1af0175 6c8ff9f0-6d45-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152636 https://www.mdpi.com/1999-4915/12/9/1001 1 b43c62a5-6d42-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152635 Veterinarska fakulteta 0 0 0