20.500.12556/RUL-134068 Surfactin facilitates horizontal gene transfer in Bacillus subtilis Genetic competence for the uptake and integration of extracellular DNA is a key process in horizontal gene transfer (HGT), one of the most powerful forces driving the evolution of bacteria. In several species, development of genetic competence is coupled with cell lysis. Using Bacillus subtilis as a model bacterium, we studied the role of surfactin, a powerful biosurfactant and antimicrobial lipopeptide, in genetic transformation. We showed that surfactin itself promotes cell lysis and DNA release, thereby promoting HGT. These results, therefore, provide evidence for a fundamental mechanism involved in HGT and significantly increase our understanding of the spreading of antibiotic resistance genes and diversification of microbial communities in the environment. quorum sensing competence surfactin DNA exchange extracellular DNA cell lysis horizontal gene transfer Bacillus subtilis zaznavanje kvoruma horizontalni prenos genov surfaktin true false true Angleški jezik Slovenski jezik Članek v reviji 2021-12-23 12:05:13 2021-12-23 12:05:14 2023-03-24 03:37:00 0000-00-00 00:00:00 2021 0 0 8 str. art. 657407 Vol. 12 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579.22/.26:579.852.11 1664-302X 10.3389/fmicb.2021.657407 58756355 RAZ_Danevcic_Tjasa_2021.pdf RAZ_Danevcic_Tjasa_2021.pdf 1 B10AAD37385433147A3DA6356F1EE484 875172be8e9e7f77f67c49c3a5bb184c8820345149758d71ae32d644ed91289f 35dd7bb5-63e2-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152392 https://www.frontiersin.org/articles/10.3389/fmicb.2021.657407/full 0 41bcc35c-63e2-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152393 Biotehniška fakulteta 0 0 0