20.500.12556/RUL-133711 Wide-antimicrobial spectrum of picolinium salts Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C$_{14}$ and C$_{16}$ side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe. picolinium salts quaternary ammonium compounds surfactant critical micellar concentration antimicrobial activity cytotoxicity pikolinijeve soli kvartarne amonijeve spojine surfaktant kritična micelarna koncentracija protimikrobna aktivnost citotoksičnost true false true Angleški jezik Slovenski jezik Članek v reviji 2021-12-10 12:00:37 2021-12-10 12:00:38 2022-09-13 03:52:15 0000-00-00 00:00:00 2020 0 0 16 str. iss. 9, art. 2254 Vol. 25 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 1420-3049 10.3390/molecules25092254 14885123 RAZ_Salajkova_Sarka_2020.pdf RAZ_Salajkova_Sarka_2020.pdf 1 C0AB759565390029171E0C3BFAB48883 d24439d9ccb88855c97ec696fe09cf5a20f7b0315df51ee72f71702c307027b3 82e96422-59a8-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152006 https://www.mdpi.com/1420-3049/25/9/2254 1 4c0de81e-59a8-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152005 Biotehniška fakulteta 0 0 0