20.500.12556/RUL-133241 Nanomedicine and immunotherapy a step further towards precision medicine for glioblastoma Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration of nanoparticles in biotechnology and their applications in medicine has allowed us to diagnose and treat disease better and more precisely. As a model disease, we used a grade IV malignant brain tumor (glioblastoma). Significant improvements in diagnosis were achieved with the application of fluorescent nanoparticles for intraoperative magnetic resonance imaging (MRI), allowing for improved tumor cell visibility and increasing the extent of the surgical resection, leading to better patient response. Fluorescent probes can be engineered to be activated through different molecular pathways, which will open the path to individualized glioblastoma diagnosis, monitoring, and treatment. Nanoparticles are also extensively studied as nanovehicles for targeted delivery and more controlled medication release, and some nanomedicines are already in early phases of clinical trials. Moreover, sampling biological fluids will give new insights into glioblastoma pathogenesis due to the presence of extracellular vesicles, circulating tumor cells, and circulating tumor DNA. As current glioblastoma therapy does not provide good quality of life for patients, other approaches such as immunotherapy are explored. To conclude, we reason that development of personalized therapies based on a patient’s genetic signature combined with pharmacogenomics and immunogenomic information will significantly change the outcome of glioblastoma patients. glioblastoma extracellular vesicles nanoscience cell free DNA circulating tumor DNA liquid biopsy immunotherapy glioblastom zunajcelični vezikli nanoznanost true false true Angleški jezik Slovenski jezik Članek v reviji 2021-11-18 08:56:35 2021-11-18 08:56:43 2022-09-12 04:15:27 0000-00-00 00:00:00 2020 0 0 33 str. iss. 3, art. 490 Vol. 25 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 1420-3049 10.3390/molecules25030490 34662361 RAZ_Samec_Neja_2020.pdf RAZ_Samec_Neja_2020.pdf 1 A8EEDC0CE330B7D661E75D9FE7B5CD48 3647c16a989af961e872b689eb9957f865c26de3a1a2b9ca26142302a25804f8 5d0298da-4845-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151138 https://www.mdpi.com/1420-3049/25/3/490 0 491eb4cb-4845-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151137 Medicinska fakulteta 0 0 0