20.500.12556/RUL-133177 Genomic insights into Salmonella Choleraesuis var. Kunzendorf outbreak reveal possible interspecies transmission Salmonella enterica serovar Choleraesuis is a host-adapted serovar that causes serious infections in domestic pigs and wild boars. Here, we investigated an outbreak of salmonellosis in domestic pigs in Slovenia, 2018–2019. To assess the outbreak, 18 isolates from domestic pigs, wild boars, wild boar meat and a human patient underwent whole-genome sequencing (WGS). All isolates were of sequence type (ST) 145 and harbored no antimicrobial resistance genes or AMR-associated mutations. A single transmission cluster (≤ 6 alleles) of spatially (< 100 km) and temporally linked isolates was observed, comprising isolates of pig (n = 9), wild boar (n = 2) and human (n = 1) origin, and suggesting possible interspecies transmission. In all outbreak-related animal cases, septicemic salmonellosis was observed, accompanied in some cases by enteric symptoms. All pig isolates were linked to a single intensive breeding farm that distributed growers to small family farms. The same transport vehicles were used to distribute growers to family farms and also to transport livestock between neighboring countries. Both isolates that originated from the imported wild boar meat were genetically distant (≥ 122 alleles) from the outbreak cluster. The present results indicate the importance of screening domestic pigs and proper disinfection of transport vehicles to control the spread of S. Choleraesuis. Salmonella Choleraesuis whole-genome sequencing domestic pig wild boar outbreak investigation true false true Angleški jezik Ni določen Članek v reviji 2021-11-16 07:24:26 2021-11-16 07:24:27 2022-09-12 04:15:13 0000-00-00 00:00:00 2021 0 0 6 str. art. 109282 Vol. 263 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.09:579 1873-2542 10.1016/j.vetmic.2021.109282 84933891 RAZ_Papic_Bojan_2021.pdf RAZ_Papic_Bojan_2021.pdf 1 0756F1B8EF7F24FE96D54A188D0705B4 fa8c56257fa819d85280c46e4b2eab0e1e187bc7cd630abd8bef890cf3d8aed5 19bc3780-46a9-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151051 https://www.sciencedirect.com/science/article/pii/S0378113521003059 0 c809547d-46a5-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151050 Veterinarska fakulteta Medicinska fakulteta 0 0 0