20.500.12556/RUL-133137 Inflammatory immune responses in patients with tick-borne encephalitis dynamics and association with the outcome of the disease Information on the association of inflammatory immune responses and disease outcome after tick-borne encephalitis (TBE) is limited. In the present study, we assessed the levels of 24 cytokines/chemokines associated with innate and adaptive immune responses in matched serum and cerebrospinal fluid (CSF) samples of 81 patients at first visit, and in serum at follow-up time points. Serum levels of several cytokines/chemokines obtained during the meningoencephalitic phase of TBE differed compared to the levels at a follow-up visit 2 months later; several significant differences were also found in cytokine/chemokine levels in serum at 2 months compared to the last time point, 2–7 years after acute illness. Cytokines/chemokines levels in CSF or serum obtained at the time of acute illness or serum levels obtained 2 months after the onset of TBE did not have predictive value for an unfavorable outcome 2–7 years later. In contrast, serum levels of mediators associated with Th17 responses were lower in patients with unfavorable outcome whereas those associated with other adaptive or innate immune responses were higher at the last visit in those with an unfavorable outcome. These findings provide new insights into the immunopathogenesis of TBE and implicate inflammatory immune responses with post-encephalitic syndrome years after the initial infection. tick-borne encephalitis outcome post-encephalitic syndrome inflammatory mediators cytokines chemokines immunopathogenesis innate immune responses adaptive immune responses true false true Angleški jezik Ni določen Članek v reviji 2021-11-12 13:20:49 2021-11-12 13:20:50 2022-09-12 04:15:03 0000-00-00 00:00:00 2019 0 0 16 str. iss. 11, art. 514 Vol. 7 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2076-2607 10.3390/microorganisms7110514 6634156 RAZ_Bogovic_Petra_2019.pdf RAZ_Bogovic_Petra_2019.pdf 1 086418A7E1C3ED2E75218D5A29396116 fa1eb4cb433029ba46367508789fc182ce78a2e5ea864071568de9ec44f9a6ac 536c30ea-43b3-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150960 https://www.mdpi.com/2076-2607/7/11/514 1 e9abfaec-43b2-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150959 Medicinska fakulteta 0 0 0