20.500.12556/RUL-133107 The role of IgA in the pathogenesis of IgA nephropathy Immunoglobulin A (IgA) is the most abundant antibody isotype produced in humans, predominantly present in the mucosal areas where its main functions are the neutralization of toxins, prevention of microbial invasion across the mucosal epithelial barrier, and simultaneous maintenance of a physiologically indispensable symbiotic relationship with commensal bacteria. The process of IgA biosynthesis, interaction with receptors, and clearance can be disrupted in certain pathologies, like IgA nephropathy, which is the most common form of glomerulonephritis worldwide. This review summarizes the latest findings in the complex characteristics of the molecular structure and biological functions of IgA antibodies, offering an in-depth overview of recent advances in the understanding of biochemical, immunologic, and genetic factors important in the pathogenesis of IgA nephropathy. IgA IgA nephropathy mucosal immunity immunoglobulin A true false true Angleški jezik Ni določen Članek v reviji 2021-11-11 11:28:01 2021-11-11 11:28:01 2022-09-12 04:14:54 0000-00-00 00:00:00 2019 0 0 19 str. iss. 24, art. 6199 Vol. 20 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 1422-0067 10.3390/ijms20246199 6761388 RAZ_Perse_Martina_2019.pdf RAZ_Perse_Martina_2019.pdf 1 E554EF2963B6CAD849590B0ADB9B3B2D 987ad70cab97b8d01510b8e915df86e0bc23e06dbfbd51f4198927b7b6d070df 34b66e7b-42da-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150908 https://www.mdpi.com/1422-0067/20/24/6199 1 fceee1ec-42d9-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150907 Medicinska fakulteta 0 0 0