20.500.12556/RUL-132360 Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease OBJECTIVE To determine the dose of coenzyme Q10 (CoQ10) needed to achieve at least a 3-fold increase in plasma CoQ10 concentration in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure (CHF). ANIMALS 18 dogs with CHF due to MMVD and 12 healthy dogs. PROCEDURES In a randomized, double-blinded, controlled trial, dogs with MMVD were given 50 or 100 mg of water-soluble CoQ10 (ubiquinone; total daily dose, 100 mg [n = 5] or 200 mg [6]) or a placebo (7), PO, twice a day for 2 weeks in addition to regular cardiac treatment. Plasma CoQ10 concentration was measured in dogs with MMVD before (baseline) and at various time points after supplementation began and in healthy dogs once. Concentrations were compared among and within groups. RESULTS No significant difference in median baseline plasma CoQ10 concentration was detected between healthy dogs and dogs with MMVD. Fold increases in plasma CoQ10 concentrations ranged from 1.7 to 4.7 and 3.2 to 6.8 for in- dividual dogs in the 100-mg and 200-mg groups, respectively. The change in plasma CoQ10 concentration after supplementation began was significantly higher than in the placebo group at 4 hours and 1 and 2 weeks for dogs in the 200-mg group and at 1 and 2 weeks for dogs in the 100-mg group. CONCLUSIONS AND CLINICAL RELEVANCE A daily CoQ10 dose of 200 mg was sufficient to achieve at least a 3-fold increase in plasma CoQ10 concentration and may be used in CoQ10 supple- mentation studies involving dogs with CHF due to MMVD. congestive heart failure coenzyme Q10 myxomatous mitral valve disease dogs true false true Angleški jezik Ni določen Članek v reviji 2021-10-22 13:39:58 2021-10-22 13:39:59 2022-09-12 04:12:06 0000-00-00 00:00:00 2021 0 0 Str. 280-285 no. 4 Vol. 82 2021 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 2020-08-17 0000-00-00 2021-04-15 636.09:616 0002-9645 10.2460/ajvr.82.4.280 57671939 RAZ_Druzhaeva_N._2021.docx RAZ_Druzhaeva_N._2021.docx 1 1B990652128DEC72D723FAF05497B941 4d95905f7c3c33193818d8ec85a55c97be2f1b5cf0306d2e2526c5b52bad6b52 13337a5d-36ef-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150115 https://avmajournals.avma.org/doi/10.2460/ajvr.82.4.280 Dostopno z geslom 1 c67a0f8c-332c-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149986 Veterinarska fakulteta 0 0 0