20.500.12556/RUL-132320 Inflammatory immune responses in the pathogenesis of tick-borne encephalitis Clinical manifestations of tick-borne encephalitis (TBE) are thought to result from the host immune responses to infection, but knowledge of such responses is incomplete. We performed a detailed clinical evaluation and characterization of innate and adaptive inflammatory immune responses in matched serum and cerebrospinal fluid (CSF) samples from 81 adult patients with TBE. Immune responses were then correlated with laboratory and clinical findings. The inflammatory immune responses were generally site-specific. Cytokines and chemokines associated with innate and Th1 adaptive immune responses were significantly higher in CSF, while mediators associated with Th17 and B-cell responses were generally higher in serum. Furthermore, mediators associated with innate and Th1 adaptive immune responses were positively associated with disease severity, whereas Th17 and B cell immune responses were not. During the meningoencephalitic phase of TBE, innate and Th1 adaptive inflammatory mediators were highly concentrated in CSF, the site of the disease. The consequence of this robust immune response was more severe acute illness. In contrast, inflammatory mediators associated with B cell and particularly Th17 responses were concentrated in serum. These findings provide new insights into the immunopathogenesis of TBE and implicate innate and Th1 adaptive responses in severity and clinical presentation of acute illness. tick-borne encephalitis inflammatory mediators innate immunity adaptive immunity cytokines chemokines cerebrospinal fluid severity of illness true false true Angleški jezik Ni določen Članek v reviji 2021-10-21 12:04:14 2021-10-21 12:04:15 2022-09-12 04:11:53 0000-00-00 00:00:00 2019 0 0 16 str. iss. 5, art. 731 Vol. 8 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2077-0383 10.3390/jcm8050731 6109612 RAZ_Bogovic_Petra_2019.pdf RAZ_Bogovic_Petra_2019.pdf 1 F138067C25A2DA387762F8B2D55E0477 e1a6b85ec883cbebff0ef973547842142ca9fd59765eb15934c57a3bb8415de6 74c31e51-3256-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149915 https://www.mdpi.com/2077-0383/8/5/731 1 3bda5e90-3256-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149914 Medicinska fakulteta 0 0 0