20.500.12556/RUL-132244 Nanotechnology meets oncology nanomaterials in brain cancer research, diagnosis and therapy Advances in technology of the past decades led to development of new nanometer scale diagnosis and treatment approaches in cancer medicine leading to establishment of nanooncology. Inorganic and organic nanomaterials have been shown to improve bioimaging techniques and targeted drug delivery systems. Their favorable physico-chemical characteristics, like small sizes, large surface area compared to volume, specific structural characteristics, and possibility to attach different molecules on their surface transform them into excellent transport vehicles able to cross cell and/or tissue barriers, including the blood-brain barrier. The latter is one of the greatest challenges in diagnosis and treatment of brain cancers. Application of nanomaterials can prolong the circulation time of the drugs and contrasting agents in the brain, posing an excellent opportunity for advancing the treatment of the most aggressive form of the brain cancer-glioblastomas. However, possible unwanted side-effects and toxicity issues must be considered before final clinical translation of nanoparticles. nanomaterials brain cancer nanomedicine nanoparticles nanobodies blood–brain barrier glioblastoma nanodiagnostics nanotherapy nanomateriali rak možganov nanomedicina true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-19 10:20:53 2021-10-19 10:20:59 2023-03-20 14:17:46 0000-00-00 00:00:00 2019 0 0 28 str. iss. 10, art. 1588 Vol. 12 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1996-1944 10.3390/ma12101588 34313945 RAZ_Zottel_Alja_2019.pdf RAZ_Zottel_Alja_2019.pdf 1 A3ADBB04B80EA80600BCC0F18359E8FF 14d9a9ab050b37122b9b7363ec0b8a991da2076f7bf240de63810f72aa0dfe50 e50953af-30b5-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149814 https://www.mdpi.com/1996-1944/12/10/1588 1 7b130a42-30b5-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149813 Medicinska fakulteta 0 0 0