20.500.12556/RUL-132233 Inception mechanisms of tunneling nanotubes Tunneling nanotubes (TNTs) are thin membranous tubes that interconnect cells, representing a novel route of cell-to-cell communication and spreading of pathogens. TNTs form between many cell types, yet their inception mechanisms remain elusive. We review in this study general concepts related to the formation and stability of membranous tubular structures with a focus on a deviatoric elasticity model of membrane nanodomains. We review experimental evidence that tubular structures initiate from local membrane bending facilitated by laterally distributed proteins or anisotropic membrane nanodomains. We further discuss the numerical results of several theoretical and simulation models of nanodomain segregation suggesting the mechanisms of TNT inception and stability. We discuss the coupling of nanodomain segregation with the action of protruding cytoskeletal forces, which are mostly provided in eukaryotic cells by the polymerization of f-actin, and review recent inception mechanisms of TNTs in relation to motor proteins. tunneling nanotubes filopodia anisotropic membrane domains cytoskeletal forces f-actin nanotube filopodija anizotropne membranske inkluzije citoskeletne sile f-aktin true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-18 14:31:47 2021-10-18 14:31:48 2022-09-12 04:11:33 0000-00-00 00:00:00 2019 0 0 17 str. iss. 6, art. 626 Vol. 8 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 2073-4409 10.3390/cells8060626 12576084 RAZ_Drab_Mitja_2019.pdf RAZ_Drab_Mitja_2019.pdf 1 639418F0F840E3DB3C272FD170E78170 3d5881a54f7d90bfcee70eba7f4be4a1c86ea4c6a2a25492bec004b45d4c7508 c293dd42-300f-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149794 https://www.mdpi.com/2073-4409/8/6/626 1 5ac60161-300f-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149793 Fakulteta za elektrotehniko Medicinska fakulteta Biotehniška fakulteta Zdravstvena fakulteta 0 0 0