20.500.12556/RUL-132092 Results of dynamic contrast-enhanced ultrasound correlate with treatment outcome in canine neoplasia treated with electrochemotherapy and interleukin-12 plasmid electrotransfer Electrochemotherapy (ECT) and/or gene electrotransfer of plasmid DNA encoding interleukin-12 (GET pIL-12) are effective treatments for canine cutaneous, subcutaneous, and maxillofacial tumors. Despite the clinical efficacy of the combined treatments of ECT and GET, data on parameters that might predict the outcome of the treatments are still lacking. This study aimed to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) results of subcutaneous tumors differ between tumors with complete response (CR) and tumors without complete response (non-CR) in dogs treated with ECT and GET pIL-12. Eight dogs with a total of 12 tumor nodules treated with ECT and GET pIL-12 were included. DCE-US examinations were performed in all animals before and immediately after therapy as well as 8 h and 1, 3, and 7 days later. Clinical follow-up examinations were performed 7 and 14 days, 1 and 6 months, and 1 year after treatment. Numerous significant differences in DCE-US parameters were noted between tumors with CR and non-CR tumors; perfusion and perfusion heterogeneity were lower in CR tumors than in non-CR tumors. Therefore, studies with larger numbers of patients are needed to investigate whether DCE-US results can be used to predict treatment outcomes and to make effective decisions about the need for repeated therapy or different treatment combinations in individual patients. dog contrast-enhanced ultrasonography electrochemotherapy immunotherapy gene electrotransfer bleomycin cisplatin IL-12 plasmid true false true Angleški jezik Ni določen Članek v reviji 2021-10-12 12:37:40 2021-10-12 12:37:40 2022-09-12 04:11:00 0000-00-00 00:00:00 2021 0 0 12 str art. 679073 Vol. 8 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-03-10 2021-04-09 2021-05-20 636.09:616 2297-1769 10.3389/fvets.2021.679073 63974403 RAZ_Brloznik_Maja_2021.pdf RAZ_Brloznik_Maja_2021.pdf 1 EF84E9F0DED3CCB42B7F9F9AC11EC108 9d93467b20c6b0922a301841e3ac14f0d617e8226d426f360a02dd359114698d 5334ee8e-2b49-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149614 https://www.frontiersin.org/articles/10.3389/fvets.2021.679073/full 1 6e03f29e-2b48-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149612 Veterinarska fakulteta Medicinska fakulteta Zdravstvena fakulteta 0 0 0