20.500.12556/RUL-132072 Association of uremic toxins and inflammatory markers with physical performance in dialysis patients Association of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, with low comorbidity to reduce the potential confounding of concomitant disease. Midweek pre-dialysis serum levels of asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, and urea were analyzed as predictor parameters of physical performance measures in adjusted models. Serum levels of most measured toxins were not significantly related to performance, except for ADMA, which was significantly related to poorer performance in the STS-10 test (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP was associated with poorer results in the 6MWT (B = −2.6 ± 0.97 m, p < 0.01) and a lower HAP score (B = −0.36 ± 0.14, p = 0.01). There were no other significant associations found. We conclude that inflammation may be a more important pathway to physical impediment than uremic toxemia. This suggests that there is a large physical rehabilitation potential in non-inflamed uremic patients. hemodialysis 6-minute walk test sit-to-stand test handgrip strength Human Activity Profile sarcopenia muscle asymmetric dimethyl-arginine C-reactive protein motor ability true false true Angleški jezik Ni določen Članek v reviji 2021-10-11 13:08:23 2021-10-11 13:08:26 2022-09-12 04:10:54 0000-00-00 00:00:00 2018 0 0 12 str. iss. 10, art. 403 Vol. 10 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.61-78:616-074 2072-6651 10.3390/toxins10100403 4610417 RAZ_Pajek_Maja_2018.pdf RAZ_Pajek_Maja_2018.pdf 1 56637FEFB7C129295F5561BAE4B84E4D 14df7f231660b71b91bf191001c667d33a8e816868b782625a007119a91cc9b9 ea17c892-2a83-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149581 https://www.mdpi.com/2072-6651/10/10/403 0 8fea745c-2a83-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149580 Fakulteta za šport 0 0 0