20.500.12556/RUL-132015 New insights into the evolutionary and genomic landscape of molluscum contagiosum virus (MCV) based on nine MCV1 and six MCV2 complete genome sequences Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response. molluscum contagiosum virus complete genome recombination immune evasion evolution genetic landscape virus molluscum contagiosum popolni genom rekombinacija true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-08 16:03:03 2021-10-08 16:03:05 2022-09-12 04:10:39 0000-00-00 00:00:00 2018 0 0 24 str. iss. 11, art. 586 Vol. 10 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 1999-4915 10.3390/v10110586 34025433 RAZ_Zorec_Tomaz_Mark_2018.pdf RAZ_Zorec_Tomaz_Mark_2018.pdf 1 2D4C0E906CDEC74F909FC03DD567084D fbaf0f0cc58dec2391a8e2e22677aa53c8dde3da99bab4174879cd5a0554f3ff 8434fa23-2841-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149511 https://www.mdpi.com/1999-4915/10/11/586 1 297f4ff4-2840-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149510 Medicinska fakulteta 0 0 0