20.500.12556/RUL-131969 Stress-tolerant yeasts opportunistic pathogenicity versus biocontrol potential Stress-tolerant fungi that can thrive under various environmental extremes are highly desirable for their application to biological control, as an alternative to chemicals for pest management. However, in fungi, the mechanisms of stress tolerance might also have roles in mammal opportunism. We tested five species with high biocontrol potential in agriculture (Aureobasidium pullulans, Debayomyces hansenii, Meyerozyma guilliermondii, Metschnikowia fructicola, Rhodotorula mucilaginosa) and two species recognized as emerging opportunistic human pathogens (Exophiala dermatitidis, Aureobasidium melanogenum) for growth under oligotrophic conditions and at 37 °C, and for tolerance to oxidative stress, formation of biofilms, production of hydrolytic enzymes and siderophores, and use of hydrocarbons as sole carbon source. The results show large overlap between traits desirable for biocontrol and traits linked to opportunism (growth under oligotrophic conditions, production of siderophores, high oxidative stress tolerance, and specific enzyme activities). Based on existing knowledge and these data, we suggest that oligotrophism and thermotolerance together with siderophore production at 37 °C, urease activity, melanization, and biofilm production are the main traits that increase the potential for fungi to cause opportunistic infections in mammals. These traits should be carefully considered when assessing safety of potential biocontrol agents. opportunistic pathogen biocontrol agent virulence stress tolerance secretome CAZy protease thermotolerance oligotrophism melanin siderophore biofilm true false true Angleški jezik Ni določen Članek v reviji 2021-10-07 15:09:46 2021-10-07 15:09:46 2022-09-12 04:10:27 0000-00-00 00:00:00 2019 0 0 23 str. iss. 1, art. 42 Vol. 10 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579 2073-4425 10.3390/genes10010042 4966223 RAZ_Zajc_Janja_2019.pdf RAZ_Zajc_Janja_2019.pdf 1 6BD75B9EFE64F674E4BC0BC81C2AD068 b029f2a8badb7ba87978f3364e35767859339ce39c96b9cfae208a1075a48404 ca6a2232-276f-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149442 https://www.mdpi.com/2073-4425/10/1/42 1 8c640539-276f-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149441 Biotehniška fakulteta 0 0 0