20.500.12556/RUL-131936 Astrocytes in flavivirus infections Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by which cells respond to neurotropic viruses remains fragmented. Several virus types have the ability to infect neural tissue, and astrocytes, an abundant and heterogeneous neuroglial cell type and a key element providing CNS homeostasis, are one of the first CNS cell types to get infected. Astrocytes are morphologically closely aligned with neuronal synapses, blood vessels, and ventricle cavities, and thereby have the capacity to functionally interact with neurons and endothelial cells. In this review, we focus on the responses of astrocytes to infection by neurotropic flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), and Japanese encephalitis virus (JEV), which have all been confirmed to infect astrocytes and cause multiple CNS defects. Understanding these mechanisms may help design new strategies to better contain and mitigate virus- and astrocyte-dependent neuroinflammation. astrocytes neuroinfections encephalitis flavivirus TBEV ZIKV WNV JEV astrociti nevrološke okužbe encefalitis true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-06 15:58:27 2021-10-06 15:58:31 2022-09-10 04:14:42 0000-00-00 00:00:00 2019 0 0 16 str. iss. 3, art. 691 Vol. 20 Feb. 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1422-0067 10.3390/ijms20030691 34184153 RAZ_Potokar_Maja_2019.pdf RAZ_Potokar_Maja_2019.pdf 1 1DD099DC4A11B6497C9829AFA58F1D53 ca3435a367c21f4b0bd5a500b678f48951640f550072b637b0531212b497886e 6411ebfe-26ad-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149395 https://www.mdpi.com/1422-0067/20/3/691 1 31fb4b23-26ad-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149394 Medicinska fakulteta 0 0 0