20.500.12556/RUL-131880 Synthesis of non-racemic pyrazolines and pyrazolidines by [3+2] cycloadditions of azomethine imines Asymmetric [3+2] cycloadditions of azomethine imines comprise a useful synthetic tool for the construction of pyrazole derivatives with a variable degree of saturation and up to three stereogenic centers. As analogues of pyrrolidines and imidazolidines that are abundant among natural products, pyrazoline and pyrazolidine derivatives represent attractive synthetic targets due to their extensive applications in the chemical and medicinal industries. Following the increased understanding of the mechanistic aspect of metal-catalyzed and organocatalyzed [3+2] cycloadditions of 1,3-dipoles gained over recent years, significant strides have been taken to design and develop new protocols that proceed efficiently under mild synthetic conditions and duly benefit from superior functional group tolerance and selectivity. In this review, we represent the current state of the art in this field and detailed methods for the synthesis of non-racemic pyrazolines and pyrazolidines via [3+2] metal and organocatalyzed transformations reported since the seminal work of Kobayashi et al. and Fu et al. in 2002 and 2003 up to the end of year 2017. pyrazolines pyrazolidines metal-catalyzed cycloadditions organocatalyzed cycloadditions azomethine imines [3+2] cycloadditions pirazolini pirazolidini kovinsko katalizirane cikloadicije organokatalizirane cikloadicije azometin imini [3+2] cikloadicije true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-05 14:14:48 2021-10-05 14:14:48 2022-09-10 04:14:21 0000-00-00 00:00:00 2018 0 0 31 str. iss. 1, art. 3 Vol. 23 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.77 1420-3049 10.3390/molecules23010003 1537674179 RAZ_Pozgan_Franc_2018.pdf RAZ_Pozgan_Franc_2018.pdf 1 10DBDA7A14484D20807E29FFAEA1B884 cc7f7a47a19e27e7295c46e5d27d9339e8f7316b459b6eac39790aa86952392c c5edb226-25d5-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149320 http://www.mdpi.com/1420-3049/23/1/3 0 8b1d83f1-25d5-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149319 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0