20.500.12556/RUL-131860 Overview of oxidative stress response genes in selected halophilic fungi Exposure of microorganisms to stress, including to high concentrations of salt, can lead to increased production of reactive oxygen species in the cell. To limit the resulting damage, cells have evolved a variety of antioxidant defenses. The role of these defenses in halotolerance has been proposed before. Whole genome sequencing for some of the most halotolerant and halophilic fungal species has enabled us to investigate the possible links between oxidative and salt stress tolerance on the genomic level. We identified genes involved in oxidative stress response in the halophilic basidiomycete Wallemia ichthyophaga, and halotolerant ascomycetous black yeasts Hortaea werneckii and Aureobasidium pullulans, and compared them to genes from 16 other fungi, both asco- and basidiomycetes. According to our results, W. ichthyophaga can survive salinities detrimental to most other organisms with only a moderate number of oxidative stress response genes. In other investigated species, however, the maximum tolerated salinity correlated with the number of genes encoding three major enzymes of the cellular oxidative stress response: superoxide dismutases, catalases, and peroxiredoxins. This observation supports the hypothetical link between the antioxidant capacity of cells and their halotolerance. oxidative stress reactive oxidative species halophilic fungi halotolerant fungi peroxidase catalase Wallemia ichthyophaga Hortaea werneckii Aureobasidium pullulans true false true Angleški jezik Ni določen Članek v reviji 2021-10-05 08:33:14 2021-10-05 08:33:15 2022-09-10 04:14:13 0000-00-00 00:00:00 2018 0 0 13 str. iss. 3, art. 143 Vol. 9 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579 2073-4425 10.3390/genes9030143 4632911 RAZ_Gostincar_Cene_2018.pdf RAZ_Gostincar_Cene_2018.pdf 1 1A6D70073E492B31B53C2179AB703995 dd68daf00a6fb4ea7b52c196d26837335e2bddc0e9cc437e6289e7fca872c5e6 23cf5a8d-25a6-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149284 http://www.mdpi.com/2073-4425/9/3/143 1 d4b4ffaa-25a5-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149283 Biotehniška fakulteta 0 0 0