20.500.12556/RUL-131823 Polymer-mediated delivery of siRNAs to hepatocellular carcinoma variables affecting specificity and effectiveness Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment efficacy can come from the enhancement of drug specificity. This goal may be achieved by combining the use of therapeutic molecules with tumor specific effects and delivery carriers with tumor targeting ability. In this regard, nucleic acid-based drug (NABD) and particularly small interfering RNAs (siRNAs), are attractive molecules due to the possibility to be engineered to target specific tumor genes. On the other hand, polymeric-based delivery systems are emerging as versatile carriers to generate tumor-targeted delivery systems. Here we will focus on the most recent findings in the selection of siRNA/polymeric targeted delivery systems for hepatocellular carcinoma (HCC), a human tumor for which currently available therapeutic approaches are poorly effective. In addition, we will discuss the most attracting and, in our opinion, promising siRNA-polymer combinations for HCC in relation to the biological features of HCC tissue. Attention will be also put on the mathematical description of the mechanisms ruling siRNA-carrier delivery, this being an important aspect to improve effectiveness reducing the experimental work. optimized drug delivery anticancer drugs HCC siRNA izboljšana dostava učinkovin onkološka zdravila rak jeter hepatocelularni rak true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-04 12:24:33 2021-10-04 12:24:39 2022-09-10 04:14:01 0000-00-00 00:00:00 2018 0 0 24 str. iss. 4, art. 777 Vol. 23 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.6/.7 1420-3049 10.3390/molecules23040777 2895739 RAZ_Farra_Rossella_2018.pdf RAZ_Farra_Rossella_2018.pdf 1 042DABD70206C24FE6A10208C6FFD946 bb60e79a8a9bd435ee36d773df0ce0e9e03114ee767f359982ba74c137712c82 4a2412c3-24fd-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149237 http://www.mdpi.com/1420-3049/23/4/777 1 fddcf266-24fc-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149236 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0