20.500.12556/RUL-131542 Astrocyte aquaporin dynamics in health and disease The family of aquaporins (AQPs), membrane water channels, consists of diverse types of proteins that are mainly permeable to water; some are also permeable to small solutes, such as glycerol and urea. They have been identified in a wide range of organisms, from microbes to vertebrates and plants, and are expressed in various tissues. Here, we focus on AQP types and their isoforms in astrocytes, a major glial cell type in the central nervous system (CNS). Astrocytes have anatomical contact with the microvasculature, pia, and neurons. Of the many roles that astrocytes have in the CNS, they are key in maintaining water homeostasis. The processes involved in this regulation have been investigated intensively, in particular regulation of the permeability and expression patterns of different AQP types in astrocytes. Three aquaporin types have been described in astrocytes: aquaporins AQP1 and AQP4 and aquaglyceroporin AQP9. The aim here is to review their isoforms, subcellular localization, permeability regulation, and expression patterns in the CNS. In the human CNS, AQP4 is expressed in normal physiological and pathological conditions, but astrocytic expression of AQP1 and AQP9 is mainly associated with a pathological state. aquaporin (AQP) astrocyte brain edema glia aquaporin isoforms orthogonal arrays of particles (OAPs) akvaporin astrocit možganski edem true false true Angleški jezik Slovenski jezik Članek v reviji 2021-09-29 09:19:40 2021-09-29 09:19:42 2022-09-10 04:12:20 0000-00-00 00:00:00 2016 0 0 18 str. iss. 7, art. 1121 Vol. 17 Jul. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1422-0067 10.3390/ijms17071121 32739033 RAZ_Potokar_Maja_2016.pdf RAZ_Potokar_Maja_2016.pdf 1 753E58A46BDDF2ADB0FEEB6A8688BE69 fc13552d7d24d06042515a893fd0916aaf786aa7b06fa50720320dc304d5b45e 9a86c9a6-20f5-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=148897 http://www.mdpi.com/1422-0067/17/7/1121 1 55e5d2c3-20f5-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=148896 Medicinska fakulteta 0 0 0