20.500.12556/RUL-131532 Raziskava stereoselektivnih dialkilacij oksazolopiperidonskih laktamov, pridobljenih iz R-fenilglicinola in (1R, 2S)-aminoindanola Stereoselective dialkylation studies in R-phenylglycinol- and (1R, 2S)-aminoindanol-derived oxazolopiperidone lactams Na področju asimetrične sinteze so oksazolopiperidonski laktami nedvomno odlični modeli za sintezo piperidinskih bioaktivnih spojin. Priprava omenjenih laktamov je mogoča v enem sinteznem koraku s ciklokondenzacijo delta-keto estra z enantiočistim amino alkoholom, običajno (R)-fenilglicinolom. Konformacijska togost in splošna funkcionalnost laktamov omogočata uvedbo obilice raznolikih substituentov na regio- in stereokontroliran način na mnoge položaje piperidinskega obroča. In the field of asymmetric synthesis, oxazolopiperidone lactams are undoubtedly excellent scaffolds for the synthesis of piperidine-containing bioactive compounds. Access to these lactams is readily available in a single synthetic step by cyclocondensation reaction of a delta-keto ester with an enantiopure aminoalcohol, usually (R)-phenylglycinol. Because of their versatile functionality and conformational rigidity, it is possible to introduce substituents at different positions of the piperidine ring in a regio- and stereocontrolled manner. oksazolopiperidonski laktami R-fenilglicinol (1R 2S)-(+)-cis-1-amino-2-indanol enolna alkilacija asimetrična sinteza oxazolopiperidone lactams R-phenylglycinol (1R 2S)-(+)-cis-1-amino-2-indanol enolate alkylation asymmetric synthesis true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2021-09-29 08:45:02 2021-09-29 08:45:04 2022-09-10 04:12:16 0000-00-00 00:00:00 2021 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 84925 4308.pdf 4308.pdf 1 7DD4AA1A285FAD450FEEEA342E8702A2 7cd38d6478f5aff711c85de4b0507593ece190189296c489ac0f02ca2cfcdd41 7eab2dba-20f0-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=148884 Fakulteta za farmacijo 0 0 0