20.500.12556/RUL-131180 Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi). Seventeen dogs were randomized into two groups (treated with BChEi and untreated) and followed for 6 months at regular check-ups. The dogs’ cognitive status was determined by a Canine Dementia Scale (CADES) questionnaire and two cognitive tests. In dogs with moderate cognitive impairment, treatment caused significant improvement in the clinical rating of cognitive abilities and the performance-based tests of cognitive functioning when compared to the untreated group (p < 0.001). Dogs treated with BChEi showed markedly improved cognitive function with enhanced quality of life. No side effects were observed in the treated dogs with moderate cognitive impairment. According to the results of this preliminary study, there is an indication that novel BChEi may be a promising drug for the treatment of CCD in dogs and may be an interesting candidate for the treatment of Alzheimer's disease in humans. However, further clinical studies are needed to confirm this. Alzheimer’s disease butyrylcholinesterase butyrylcholinesterase inhibitor canine cognitive dysfunction canine dementia scale dogs true false true Angleški jezik Ni določen Članek v reviji 2021-09-23 09:13:15 2021-09-23 09:13:15 2022-09-10 04:10:27 0000-00-00 00:00:00 2021 0 0 10 str. art. 18098 Vol. 11 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2020-12-15 2021-08-17 2021-09-13 636.7.09:616.892 2045-2322 10.1038/s41598-021-97404-2 77000195 RAZ_Zakosek_Maja_2021.pdf RAZ_Zakosek_Maja_2021.pdf Open access 1 2A7E6FFD649C1E4BB4A045BC8C9556C4 1602094712886f1dc8856a9e22e6130a83a2f8c6ccfe762725bede9512d974db 738cbf81-1c3d-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=148446 https://www.nature.com/articles/s41598-021-97404-2 0 3f95581f-1c63-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=148506 Veterinarska fakulteta Fakulteta za farmacijo 0 0 0