20.500.12556/RUL-130385 Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions. Alzheimer's disease autophagy Parkinson's disease neurodegeneration prion diseases proteostasis unfolded protein response Alzheimerjeva bolezen avtofagija Parkinsonova bolezen true false true Angleški jezik Slovenski jezik Članek v reviji 2021-09-14 10:18:17 2021-09-14 10:18:19 2022-09-09 04:16:11 0000-00-00 00:00:00 2015 0 0 Str. 22718-22756 iss. 12 Vol. 20 Oct. 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 1420-3049 10.3390/molecules201219865 32400601 RAZ_Milisav_Irina_2015.pdf RAZ_Milisav_Irina_2015.pdf 1 3EB1D3A78733572DB4505787C43D5054 5f5ddc80d6338b79e8a1c6c69fba9ebe4e075ee56baf49bd6c223582da1bca77 83c5dafc-1534-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147486 http://www.mdpi.com/1420-3049/20/12/19865 0 10d209a8-1534-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147484 Medicinska fakulteta Zdravstvena fakulteta 0 0 0