20.500.12556/RUL-130298 Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC$_{50}$ = 1.28 % 0.03 µM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line. Alzheimer's disease quinazolinones multicomponent reactions multitarget-directed ligands antioxidants cholinesterase inhibitors hepatotoxicity Alzheimerjeva bolezen true false true Angleški jezik Slovenski jezik Članek v reviji 2021-09-13 10:40:53 2021-09-13 10:40:54 2022-09-09 04:15:46 0000-00-00 00:00:00 2016 0 0 15 str. iss. 5, art. 634 Vol. 21 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.2:616.894 1420-3049 10.3390/molecules21050634 4083825 RAZ_Dgachi_Youssef_2016.pdf RAZ_Dgachi_Youssef_2016.pdf 1 F17E0E349251A9EC0CD5CFB4D3835FC6 cafdaf62164694550c0269e7597b08879c70a56d4cb7b10873779dc7b43711df b8af3eac-146e-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147372 http://www.mdpi.com/1420-3049/21/5/634 0 0e7fe742-146e-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147371 Fakulteta za farmacijo 0 0 0