20.500.12556/RUL-129867 Vloga elektrostatskih interakcij v proteinskih sistemih The role of electrostatic interactions in protein systems V svoji diplomski nalogi sem se osredotočila na vlogo elektrostatskih interakcij v proteinskih sistemih. Orisala sem dva implicitna teoretična modela za obravnavo elektrostatike pri proteinih: Bornov in Poisson-Boltzmannov model. Elektrostatske interakcije so pri proteinih močno odvisne od njihove zgradbe, pa tudi od pH raztopine, temperature, prisotnosti soli in kofaktorjev. Igrajo zelo pomembno vlogo (zlasti vodikova vez in solni mostički) na zvijanje in s tem na strukturo proteinov. Pomembne so tudi za topnost proteinov, interakcije proteinov z drugimi biološkimi molekulami ter interakcije protein-protein, zaradi katerih pride do samozdruževanja le-teh. Proteini se lahko tudi napačno zvijejo, kar vodi do agregacije. Ti agregati se začnejo kopičiti v tkivu, zaradi česa celica ne more več opravljati svoje funkcije, kar vodi do nastanka nevrodegenerativnih bolezni. Te bolezni so danes zelo razširjene, na žalost pa so še vedno neozdravljive. In my diploma, I focused on the role of electrostatic interactions in protein systems. Outline of two implicit theoretical models used for treating electrostatics in systems containing proteins will be given: the Born and the Poisson-Boltzmann model. Electrostatic interactions are strongly dependent on the protein composition, as well as on pH, temperature, presence of salts, and cofactors. They play a very important role (especially hydrogen bonding and salt bridges) in folding and thus in protein structure. They are also important for protein solubility, protein interactions with other biological molecules, and protein-protein interactions that lead to protein self-aggregation, as proteins in the vast majority of cases do not act on their own. Proteins can also be misfolded, which leads to protein aggregation. These aggregates begin to accumulate in the tissue, causing the cell to no longer be able to perform its function, leading to the development of neurodegenerative diseases. These diseases are very common today, but unfortunately they are still not curable proteini aminokisline elektrostatske interakcije vodikova vez solni mostički protein-protein interakcije Hofmeistrova vrsta agregacija proteinov proteins amino acids electrostatic interactions hydrogen bonding salt bridges protein-protein interactions Hofmeister series protein aggregation true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2021-09-09 07:30:00 2021-09-09 07:30:03 2022-09-09 04:13:38 0000-00-00 00:00:00 2021 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 17561 81929219 Avdicevic_Adela_-_Vloga_elektrostatskih_interakcij_v_proteinskih_sistemih.pdf Avdicevic_Adela_-_Vloga_elektrostatskih_interakcij_v_proteinskih_sistemih.pdf 1 6C34F65E9F487A4763309CCC538429B0 946b0b026631915b6fa7f13500e52244056ed2f8a86ccdd22f66814e92bb5c92 bcf3d6b1-112e-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146900 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0