20.500.12556/RUL-129834 Sinteza in uporaba 2-naftolnega derivata Synthesis and application of 2-naphthol derivative Alzheimerjeva bolezen je ena izmed najbolj raziskovanih nevrodegenerativnih bolezni. Gre za progresivno nevrološko motnjo, ki zmanjša velikost možganov in vodi k odmrtju možganskih celic. Fluorescenčne sonde se pogosto uporabljajo v kliničnih raziskavah in diagnozi Alzheimerjeve bolezni. V tem delu je predstavljena sinteza dveh derivatov naftola, katerih optične lastnosti bi lahko s pridom uporabljali na različnih področjih znanosti. Gre za 6-acetil-2-(dimetilamino)naftalen in 1-{6-[(2-hidroksietil)(metil)amino]-2-naftil}etanon, oba sintetizirana iz 1-(6-hidroksinaftalen-2-il)etanona. Alzheimer disease is one of the most researched neurodegenerative diseases. It is a progressive neurological disorder that reduces the size of the brain and leads to the death of brain cells. Fluorescent probes are widely used in clinical trials and the diagnosis of Alzheimer disease. This thesis presents the synthesis of two naphthol derivatives, optical properties of which could be used to advantage in various fields of science. These are 6-acetyl-2-(dimethylamino)naphthalene and 1-{6-[(2-hydroxyethyl)(methyl)amino]-2-naphthyl}ethanone, both synthesized from 1-(6-hydroxynaphthalen-2-yl)ethanone. Alzheimerjeva bolezen naftolni derivati sinteza Heckova reakcija Buchererjeva reakcija Alzheimer disease naphthol derivatives synthesis Heck reaction Bucherer reaction true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2021-09-08 15:00:04 2021-09-08 15:00:06 2022-09-09 04:13:29 0000-00-00 00:00:00 2021 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 16581 79744771 Jelenko_Leja_-_Sinteza_in_uporaba_2-naftolnega_derivata.pdf Jelenko_Leja_-_Sinteza_in_uporaba_2-naftolnega_derivata.pdf 1 6A751C094542A1894F6EC742ECE47465 2e34ad696dc5ded6e899f66837a9ae56f6e16ba5659d46ffcbc9acd68113091b 716b859b-10a4-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146866 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0